The truth is that these products may or may not assist with weight loss. But whatever their impact, it seems that we can't escape actually doing the hard yards, such as changing our diets or getting more exercise, if we want to see results. Weight-loss pills tend to contain a mix of herbs and vitamins, and often stimulants such as caffeine, which can result in high blood pressure and heart palpitations. Herbs contain many chemicals, the presence and concentration of which can vary according to the source and the preparation.
And in most of these weight-loss pills, ingredients are only individually tested for safety, despite the fact that they may interact with one another or with other medications in ways that may be less safe.
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Here we look at some of the most common ingredients in weight-loss pills, what they claim to do, and whether there's any evidence they're effective. It's a derivative of citric acid, usually extracted from the fruit rind of the plant Garcinia cambogia. It may also be listed as brindleberry, Malabar tamarind, or Garcinia gummi-gutta. Studies provide contradictory evidence. Some show positive results, while others show no difference between the group taking HCA and the placebo.
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More comprehensive studies are needed. Some studies have shown it can cause headache, nausea, and symptoms in the upper respiratory tract, stomach and intestines, and liver damage. The safety of HCA during pregnancy and breastfeeding has not been established, so it should be avoided at these times. It's been found as a standalone supplement and in weight-loss blends such as Naturopathica FatBlaster Max. An extract of the Seville orange, it's also known as Citrus aurantium. It's used in place of ephedra, as it contains similar compounds.
Bitter orange has been linked with fainting, heart attack and stroke, so people who have heart conditions or are taking other medications are advised to avoid it. Because the safety and effects of products containing bitter orange during pregnancy and breast feeding are unknown, pregnant women and nursing mothers should avoid them too.
Short-term burning pain, stomach irritation and upset, sweating, flushing, and runny nose have all been reported. In large long-term doses, more serious side effects such as liver or kidney damage could occur, as well as severe spikes in blood pressure. Capsaicin annuum may also have moderate interactions with some medications. Increases metabolism and glucose control, and helps with obesity, diabetes, high blood pressure, and Alzheimer's disease.
There are some positive results from studies, but the quality of the studies is poor. Plus there's insufficient evidence to suggest green coffee extract is effective, so more rigorous trials are needed. There are none known, but the product's safety hasn't been confirmed in a large analysis. It has the potential to increase heart rate and blood pressure, and to cause headaches.
Green coffee contains caffeine, so it may cause similar side effects as regular coffee or caffeine consumption. For that reason, it isn't recommended for people with anxiety, bleeding disorders, irritable bowel syndrome, high cholesterol or high blood pressure — it may make all these conditions worse. It may also interact with certain medications. There's not enough reliable information about the safety of taking green coffee if you're pregnant or breastfeeding, so it's better to avoid it at these times.
The results have been conflicting. Some studies suggest it needs to be taken with caffeine to be effective.
It might have a modest effect on body weight, but it hasn't been shown to produce or help maintain meaningful weight loss. Deemed safe when formulated and taken appropriately, green tea and green tea extracts contain caffeine and so may cause side effects. There's some concern that green tea extracts may cause liver toxicity, especially if taken on an empty stomach.
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Other reported adverse effects include constipation, abdominal discomfort, nausea and increased blood pressure. Also known as poliglusam, chitosan is found naturally in the cell walls of fungi, soil and sediments. But it's usually derived from the powdered shells of crustaceans.
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Clinical studies have been small and mostly of low quality. They show varying results and only minor weight loss, which is probably clinically insignificant. If it does work, you could experience malabsorption of nutrients and loose, oily stools. Other reported side effects include flatulence, bloating, constipation, indigestion, nausea and heartburn. Chromium is an essential trace element commonly used in the form of chromium picolinate. It's commonly found in small amounts in meat, wholegrains, fruits and vegetables. Enhances insulin sensitivity and fat burning.
It may also increase lean body mass and reduce food intake, hunger levels and fat cravings. Few serious adverse effects have been found, but some medications may interact with it. Chromium may also cause headache, watery stools, constipation, weakness, vertigo, nausea, vomiting and urticaria hives.
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Carnitine is composed of the amino acids lysine and methionine. You may see it listed as L-carnitine or acetyl-L-carnitine. It's naturally present in foods such as meat, fish, milk and dairy products, and in small amounts in some plant foods. L-carnitine is potentially beneficial for a range of health conditions such as obesity, diabetes, and heart disease.
It may also aid weight loss and exercise recovery.
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There have been several clinical trials with weight loss as a secondary outcome. They have indicated that carnitine may have a modest effect on body weight, although more research on its weight-loss credentials is needed. Nausea, vomiting, diarrhoea, abdominal cramps, and a "fishy" body odour have all been reported.
L-carnitine may also increase the risk of cardiovascular disease. Conjugated linoleic acid also listed as CLA is naturally occurring polyunsaturated fatty acid present in ruminant dairy products and meat. Commercial CLA is often produced from sunflower oil. Promotes weight loss through the increased fat breakdown in the body.
It's also claimed to help maintain weight loss, retain lean muscle mass, and control diabetes. So far, studies suggest there's minimal effect on body weight and body fat, and some smaller studies show contradictory results. More studies are needed. Minor side effects have been reported, such as indigestion, abdominal discomfort and pain, constipation, diarrhoea, and loose stools. Yohimbe is derived from the bark of a West African evergreen tree Pausinystalia yohimbe, Pausinystalia johimbe. It may also be listed as johimbe or yohimbine. The extract is found in some dietary supplements that are promoted for weight loss, bodybuilding and libido enhancement in men.
Very little research has been done on the use of yohimbe for weight loss or its effect on body mass, and studies are often contradictory. There's very little conclusive evidence that it has an effect on either. Yohimbe can be dangerous. It can increase blood pressure and cause headaches, hypertension, anxiety, agitation, tachycardia, myocardial infarction heart attack , cardiac failure, and even death, depending on the dosage. It's recommended that yohimbe should only be used under medical supervision because of its potential to produce serious adverse effects.
Yohimbe extracts have been banned in many countries and the substance is considered to be a prescription-only medicine in Australia and is prohibited from being imported. Glucomannan is a soluble dietary fibre derived from konjac root Amorphophallus konjac that can absorb up to 50 times its weight in water. It's also known as conjac, konnyaku and konjonac.. Glucomannan is touted as an appetite suppressant that works by increasing feelings of satiety and fullness. It may also reduce fat and protein absorption in the gut.