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Tell your doctor right away if you become pregnant.

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Do not start or stop taking this medicine without your doctor's advice. If you are pregnant, your name may be listed on a pregnancy registry to track the effects of trazodone on the baby. It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk. Trazodone is not approved for use by anyone younger than 18 years old.

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking trazodone and call your doctor at once if you have a penis erection that is painful or lasts 6 hours or longer. This is a medical emergency and could lead to a serious condition that must be corrected with surgery. Report any new or worsening symptoms to your doctor , such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive mentally or physically , more depressed, or have thoughts about suicide or hurting yourself.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. Avoid driving or hazardous activity until you know how this medicine will affect you.

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Your reactions could be impaired. Do not use in larger or smaller amounts or for longer than recommended. Follow all directions on your prescription label and read all medication guides or instruction sheets.


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Your doctor may occasionally change your dose. Use the medicine exactly as directed. It may take up to 2 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve. Do not stop using trazodone suddenly , or you could have unpleasant symptoms such as dizziness, vomiting, agitation, sweating, confusion, numbness, tingling, or electric shock feelings.

Ask your doctor how to safely stop using this medicine. Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. Overdose symptoms may include extreme drowsiness, vomiting, penis erection that is painful or prolonged, fast or pounding heartbeat, seizure black-out or convulsions , or breathing that slows or stops. Health Topics. Special Reports. Health Tools. Trazodone Desyrel. You can report any suspected side effect to the UK safety scheme. If you become pregnant while taking trazodone, speak to your doctor.

Do not stop taking your medicine unless your doctor tells you to. But if your depression isn't treated during pregnancy, this can also increase the chance of problems. Your doctor can explain the risks and the benefits, and will help you decide which treatment is best for you and your baby.

If your doctor or health visitor says your baby is healthy, trazodone can be used during breastfeeding. Trazodone passes into breast milk in very small amounts, and hasn't been linked with any side effects. It's important to continue taking trazodone to keep you well. Breastfeeding will also benefit both you and your baby.

If you notice that your baby isn't feeding as well as usual, seems unusually sleepy, or you have any other concerns about your baby, talk to your health visitor or doctor as soon as possible.

Trazodone (Desyrel) - Side Effects, Interactions, Uses, Dosage, Warnings | Everyday Health

Many medicines and trazodone can interfere with each other and increase the chances of you having side effects. Do not take St John's wort, the herbal remedy for depression, while you're being treated with trazodone as this will increase your risk of side effects.

Tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements. Serotonin and noradrenaline are chemicals in the brain that help improve your mood.


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When your levels are low, you can get depressed. You may notice that you sleep better and get on with people more easily because you're less anxious. Trazodone won't change your personality or make you feel euphorically happy. It'll simply help you feel like yourself again. Don't expect to feel better overnight.

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Trazodone can take 1 to 2 weeks to start to work, and it can be 4 to 6 weeks before you feel the full benefit. Give the medicine at least 6 weeks to work. If you need additional help, you can also contact the Samaritans. If you have only had 1 episode of depression, you'll need to take trazodone for at least 6 months after you feel better.

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If you have had depression more than once, your doctor may recommend carrying on with trazodone for much longer. Yes, trazodone is safe to take for a long time. There don't seem to be any lasting harmful effects from taking it for many months, or even years.

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Some people need to take trazodone long term to treat depression or anxiety that keeps coming back. If you need it and don't get side effects, there's no reason to worry about taking trazodone for a long time. There's no evidence that trazodone is addictive. But you may experience extra side effects if you stop taking it suddenly.

This can cause sleep problems. It can also leave you feeling irritable and you may sweat more than usual. If you have been feeling better for 6 months or more, your doctor may suggest coming off trazodone. Your doctor will probably recommend reducing your dose gradually over several weeks, or longer if you have been taking trazodone for a long time.

This is to help prevent any extra side effects you might get as a reaction to coming off the medicine.

Doctors usually prescribe it when other antidepressants haven't worked or have caused side effects. It isn't any better or worse than other antidepressants. Some people respond better to one antidepressant than another. Your doctor will recommend an antidepressant for you based on any other health issues you may have and the medicines you have tried already.

You may find trazodone helpful if you have anxiety and problems getting to sleep, or if you're irritable and agitated.