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Reduction in body weight was 4. Appetite decreased by Some studies on herbal coffee supplements with HCA showed an increase in resting energy expenditure to enhance metabolic rates and promote weight and fat loss. A meta-analysis evaluated the efficacy of G. The meta-analysis included 12 clinical trials. There was significantly greater weight loss with G. There was considerable heterogeneity among trials, with wide variation in the duration of treatment 2 to 12 weeks and the dosage of G. An analysis restricted to the 2 studies with good methodological quality 17 , 23 found no significant difference in weight loss between G.
In the 4 studies that evaluated changes in BMI as an outcome, G. A second meta-analysis evaluated the weight-loss efficacy of natural plant extracts. Fourteen studies with an overall quality rating of 7. Five of these studies evaluated extracts that included G. One study that used a higher dose of HCA-SX reported a significant reduction in appetite effect size, 2.
The other 4 studies did not support an HCA effect on satiety. The authors concluded that the evidence for weight loss with HCA as a single ingredient is not compelling.
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A guideline for the management of overweight and obesity from the American Heart Association, the American College of Cardiology, and the Obesity Society considers drug therapy as an adjunct to lifestyle interventions for motivated individuals with a BMI of 30 or more or with a BMI of 27 or more with at least 1 obesity-related comorbid condition. The panel did not review comprehensive evidence for weight-loss pharmacotherapy. This guideline does not address the use of natural product extracts such as G.
Mice treated with G. Leptin is a hormone associated with appetite control; G. HCA promoted lipid oxidation and reduced carbohydrate use in mice at rest and during running. Antiulcer activity was observed against induced gastric mucosal injury in rats when they were pretreated with G. The activity may be associated with the iron in G. Avoid use during pregnancy and lactation due to a lack of clinical and scientific information. One study in rats documented decreased maternal body weight gain during gestation. Monitor therapy.
Iron: G. Montelukast or leukotriene receptor antagonists : One case report documented fatal liver failure in a patient taking montelukast and 2 dietary supplements, one of which included G. Potassium and calcium supplements: Some commercial G.
GARCINIA CAMBOGIA (100 Capsules)
Serotonin: A mouse study using a commercial polyherbal product containing G. Caution is advised for patients being treated for pain or taking medications for any psychiatric condition. Statins: A case report of rhabdomyolysis was documented in a patient taking a combination herbal medicine containing G. Warfarin: In one case report, the international normalized ratio of a patient returned to normal after he stopped taking a combination herbal product containing G.
Fifteen clinical studies involving approximately patients documented very mild adverse reactions, with the most common including headache, dizziness, dry mouth, and GI complaints such as nausea and diarrhea. In , the FDA announced a voluntary recall of all Hydroxycut dietary supplements for weight loss and warned consumers that the products may cause potentially fatal hepatotoxicity.
The recall involved 14 multi-ingredient products with different formulations. Prior to the recall, the primary ingredients of Hydroxycut products included G. Criteria from the Drug-Induced Liver Injury Network study were applied to 17 cases of hepatotoxicity linked to Hydroxycut, most with hepatocellular damage, including 9 of the cases reported to the FDA. Severity was moderate in 11 cases, was severe in 2 cases, required liver transplant in 4 cases, and was fatal in 1 case. Her condition deteriorated and approximately 50 days after initial symptom onset, she underwent successful liver transplantation.
Other serious adverse effects associated with Hydroxycut products that were reported to the FDA included seizures, rhabdomyolysis, and cardiovascular disorders. A near-fatal case of acute necrotizing eosinophilic myocarditis was believed to be associated with G. Despite early complications, including acute kidney injury and sustained ventricular tachycardia that required cardiopulmonary resuscitation, she survived and stabilized quickly within 24 hours of high-dose corticosteroid therapy.
Some animal studies document testicular toxicity with G. A study in obesity-prone mice evaluated long-term supplementation of a high-fat diet with G.
Weight Control
The study suggests that long-term ingestion of G. No unusual electrocardiographic effects QTc interval or other electrocardiograph variables were seen over 5 hours in patients taking half the recommended dose of a multicomponent weight loss supplement containing G.
This information relates to an herbal, vitamin, mineral or other dietary supplement. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. This information should not be used to decide whether or not to take this product. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this product.
It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This information is not specific medical advice and does not replace information you receive from your health care provider. You should talk with your health care provider for complete information about the risks and benefits of using this product. This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements.
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Skip to Content. Garcinia Medically reviewed by Drugs. Common Name s : Malabar tamarind Clinical Overview Use The medical literature primarily documents weight loss and lipid-lowering activity for G. Dosing The dosages of G. Contraindications Avoid use if there is a known allergy or hypersensitivity to any components of G. Interactions The herb has documented drug interactions. Adverse Reactions Fifteen clinical studies involving approximately patients documented very mild adverse reactions, with the most common adverse reactions including headache, dizziness, dry mouth, and GI complaints such as nausea and diarrhea.